my thrid question in your edited version, I feel the following should read correctly and want to clarify which one is correct.<br /><br />What I meant her in this paragraph is that different types of CuO NPs exhibited the extent of toxicity and the&nbsp;the most toxicity was observed from the synthesized nano-CuO (e.g., 12 times lower concentration estimated in EC<sub><span style="font-size: small;">50</span></sub>), compared to less-pure commercial nano-CuO [Torres-Duarte et al., 2015].<br /><br />my edited sentence:<br />
<p>Similarly, the dissolution of CuO NPs was shown to be the most critical parameter of assessing toxicity in estuarine and marine environments though different types of CuO NPs exhibited the extent of toxicity as the most toxicity observed from the synthesized nano-CuO (e.g., 12 times lower concentration estimated in EC<sub>50</sub>) compared to less-pure commercial nano-CuO [Torres-Duarte et al., 2015].</p>
<br /><br />your edited sentence:&nbsp;
<p>Similarly, the dissolution of CuO NPs was shown to be the most critical parameter of assessing toxicity in estuarine and marine environments though different types of CuO NPs that exhibited the extent of toxicity as the most toxicity observed from the synthesized nano-CuO (e.g., 12 times lower concentration estimated in EC<sub>50</sub>) was compared to less-pure commercial nano-CuO [Torres-Duarte et al., 2015].&nbsp;</p>
<br />please let me know soon