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<p>On the other hand, the size of industrial TiO<sub>2</sub> was decreased after contact with algae, which could be a result of leaching of surface coatings from the industrial TiO<sub>2</sub> (Liu et al., 2013 a&amp;b; Liu et al., 2014).</p>
<p>&nbsp;C6:</p>
<p><strong>Response: </strong>Additional experiments were performed and have already addressed and revised according to the results. Please refer to responses to comments 5 from this reviewer and comment 3 in reviewer 1.</p>
<p>C7:<br /><strong>Response:</strong> As written in the original manuscript, we believe that although the predicted environmental concentrations of nano-TiO2 in water were less than 20 mg/L, given that long-term exposure could cause toxic effects on marine environments, our study tested at higher concentrations of TiO<sub>2</sub> is relevant. According to recent studies, the concentrations of nano-TiO<sub>2</sub> tested for toxic effect on algae ranged from 5 to 30 mg/L (Li et al., 2015), from 5 to 100 mg/L (Xia et al., 2015), and from 5 to 200 mg/L nano-TiO<sub>2</sub> (Wang et al., 2016). We revised the last paragraph to reflect recent studies performed at higher concentrations of nano-TiO<sub>2</sub>.</p>
<p>According to recent studies, the concentrations of nano-TiO<sub>2 </sub>tested for toxic effect on algae ranged from 5 to 30 mg/L (Li et al., 2015) and from 5 to 200 mg/L nano-TiO<sub>2</sub> (Wang et al., 2016). Considering the lack of data on toxicity after long-term exposure, a further study is strongly encouraged to investigate the potential effects of long-term exposure of nano-TiO2 on marine environments under various environmental parameters.</p>